However, to date, a causal relationship has not been demonstrated between the use of varenicline and these symptoms, particularly because nicotine dependence and withdrawal syndrome are known to be linked to suicidal ideation, negative affectivity, and depressive symptoms (Jimnez-Ruiz, Berlin, & Hering, 2009

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Together, these effects can prevent the body from fully recovering overnight, which leads to cumulative sleep debt and long-term health consequences if the underlying causes are not addressed